Claude has convinced me to add Idebenone to my protocol

Yesterday somebody posted about where Melatonin fit into a supplements list of mitochondrial protectants and rebuilders.
This prompted me to ask Claude about my go to mitochondrial support supplement, Nicotinic Acid, which also rated very high.
Then Claude offered something I had not asked for:
"In a top 10 mitochondrial supplements list, I'd likely place:
Melatonin in the #3-5 range - Its multi-level protection, mitochondrial concentration, and regenerative signaling are exceptional
Nicotinic acid in the #2-4 range - NAD+ is so fundamental that without adequate levels, nothing else works optimally
The top tier would probably include CoQ10/ubiquinol (#1-2) given its direct role in the electron transport chain, followed closely by NAD+ precursors and melatonin.
Key distinction: Nicotinic acid addresses mitochondrial function and rebuilding (biogenesis), while melatonin excels at protection and damage prevention. Ideally, you'd want both working synergistically."

I did not ask about CoQ10/ubiquinol, but I know something about it.  When I first joined this group I was taking Idebenone, which is synthetic CoQ10.

So I asked Claude: How would you rate CoQ10/ubiquinol to Idebenone as a mitochondrial rebuilder? 
And one of the things Claude said was: "For general mitochondrial health and biogenesis support: CoQ10/ubiquinol rates higher - it's the natural compound your mitochondria evolved to use, and replacing depleted stores is foundational.
For damaged/dysfunctional mitochondria or neurological conditions: Idebenone rates higher - it can work around impaired complexes and reach brain mitochondria more effectively."

I told Claude I was thinking of adding Idebenone to my existing high dose Nicotinic Acid protocol for my prodromal Parkinson's Disease. 
Claude replied: "That's a very thoughtful combination for prodromal PD. The synergy between high-dose nicotinic acid and idebenone could be quite powerful:
Why this combination makes sense:
Nicotinic acid foundation:
Restores NAD+ for mitochondrial energy production and Complex I function (particularly relevant since Complex I deficiency is a hallmark of PD)
Supports mitochondrial biogenesis through sirtuin activation
May help clear damaged mitochondria and generate new ones
Some evidence for neuroprotection via GPR109A receptor activation
Adding idebenone addresses gaps:
Provides direct antioxidant protection in the substantia nigra where nicotinic acid doesn't concentrate as well
Protects existing mitochondria while nicotinic acid helps build new ones
Works even if some mitochondrial damage already exists
Complements rather than duplicates nicotinic acid's mechanisms"

We decided to go with 45 mg of Idebenone twice a day which  fairly copies this ongoing study (their is 30 mg 3 times a day): Efficacy of idebenone in the Treatment of iRBD into Synucleinopathies (EITRS): rationale, design, and methodology of a randomized, double-blind, multi-center clinical study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510988/

Claude also convinced me to start having some good oils with my morning 11 PM batches of supplements to aid absorption, so I will start:
 - Noon: Broccoli sprouts with olive oil/honey + vitamin C, methylfolate, curcumin, berberine, niacin, idebenone 45mg
 - 11 PM: Heaping tablespoon of sour cream + curcumin, berberine, niacin, idebenone 45mg 

There is a lot more in our conversation.  You are welcome to read it: https://claude.ai/share/2bdaff5d-cfd5-4e90-87ea-338911af7bfe